Drinking and arterial blood pressure responses to ANG II in young and old rats.

Crocin prevents acute angiotensin II-induced hypertension in anesthetized rats

Objective: Angiotensin II (Ang II), the main product of renin-angiotensin system (RAS) has a well-known role in cardiovascular regulation. Over-production of Ang II is one of the important underlying mechanisms of hypertension. In this study, the effect of crocin on cardiovascular responses in rats with acute hypertension induced by Ang II was evaluated. Materials and methods: Rats were divided...

Memory may not be the first thing to go: focus on "Drinking and arterial blood pressure responses to ANG II in young and old rats".

THE AGING OF THE WORLD’S POPULATION brings health problems that have the potential of exhausting health care resources, both financial and human. Many of these problems involve the debilitating results of age-related failure of organ systems and/or neurological function. In contrast, one of the most common health concerns in the elderly is a deceptively benign condition with potentially disastr...

Memory May Not Be the First Thing to Go: Focus on “drinking and Arterial Blood Pressure Responses to Angiotensin Ii in Young and Old Rats” by Thunhorst Et Al

Candesartan Attenuates Ischemic Brain Edema and Protects the Blood–Brain Barrier Integrity from Ischemia/Reperfusion Injury in Rats

Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods...

Nucleus of the solitary tract lesions enhance drinking, but not vasopressin release, induced by angiotensin.

Rats with chronic nucleus of the solitary tract lesions (NTS-X) drink water and release vasopressin (VP) in response to reduced blood volume despite an absence of neural signals from cardiac and arterial baroreceptors. The present study determined whether rats with NTS-X have a greater sensitivity to circulating ANG II, which may contribute to the drinking and VP responses to hypovolemia. In co...